Dimethylnitrosamine-Induced Liver Fibrosis and Recovery in NOD/SCID Mice
نویسندگان
چکیده
منابع مشابه
The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat.
Four to six week old, male Wistar rats were used to produce animal models of liver fibrosis. The process requires four weeks of administration of 10 mg/kg dimethylnitrosamine (DMN), given intraperitoneally for three consecutive days per week. Intraperitoneal injections were performed in the fume hood as DMN is a known hepatoxin and carcinogen. The model has several advantages. Firstly, liver ch...
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The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylactic experiment, bicyclol (100 and 200mg.kg(-1)) was administered by gavage in a...
متن کاملPterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats.
Pterostilbene, found in grapes and berries, exhibits pleiotropic effects, including anti-inflammatory, antioxidant, and anti-proliferative activities. This study was conducted to investigate the effect of pterostilbene on liver fibrosis and the potential underlying mechanism for such effect. Sprague-Dawley rats were intraperitoneally given dimethyl n-nitrosamine (DMN) (10mg/kg) 3 days per week ...
متن کاملMineral metabolism in dimethylnitrosamine-induced hepatic fibrosis.
OBJECTIVES Complications such as ascites during the pathogenesis of hepatic fibrosis and cirrhosis may lead to several abnormalities in mineral metabolism. In the present investigation, we have monitored serum and liver concentrations of calcium, magnesium, sodium and potassium during experimentally induced hepatic fibrosis in rats. DESIGN AND METHODS The liver injury was induced by intraperi...
متن کاملIron deposition and fat accumulation in dimethylnitrosamine-induced liver fibrosis in rat.
AIM To investigate if iron deposition and fat accumulation in the liver play a pathogenetic role in dimethylnitrosamine (DMN)-induced liver fibrosis in rat. METHODS Thirty rats were treated with DMN at does consecutive days of 10 microL/kg daily, i.p., for 3 consecutive day each week for 4 wk. Rats (n=30) were sacrificed on the first day (model group A) and 21(st) d (model group B) after cess...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2011
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.10-0311